Endocrine Abstracts

Background: Children with undiagnosed coeliac disease are at risk of low bone mineral density (BMD), but whether this translates to fracture predisposition is unclear. In adults with coeliac disease anti-osteoprotegerin (anti-OPG) antibodies have been identified. OPG inhibits RANK ligand activation of osteoclastic bone resorption, and thus anti-OPG antibodies promote bone loss. We report a case of osteoporosis with elevated anti-OPG antibodies in a child with coeliac disease.<...

Background: Unrecognised type I diabetes (TIDM) can have serious consequences which may be avoidable with early diagnosis. Many children have delayed diagnosis, however contributing factors are unclear.Aims: To evaluate the patient pathway before diagnosis and initial hospital management of children with TIDM.Methods: Over a 3-month period, parents of children newly diagnosed with TIDM across the UK completed a questionnaire. Addit...

Introduction: Maternal diet during pregnancy has been linked to offspring body composition, but the specific nutrients and mechanisms involved are not well understood. Higher n-3 polyunsaturated fatty acid (PUFA) status is associated with lower risk of adiposity in adults, whereas n-6 PUFA are adipogenic. The effect of maternal PUFA in determining offspring body composition is unknown.Method: We evaluated the relationships between maternal ...